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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AAK1 All Species: 6.67
Human Site: Y845 Identified Species: 20.95
UniProt: Q2M2I8 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q2M2I8 NP_055726.3 863 93578 Y845 A C F K N D K Y L V N Q S L G
Chimpanzee Pan troglodytes XP_001138187 865 93810 Y847 A C F K N D K Y L V N Q S L G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_531855 473 51892 Q456 A Q A T P Q H Q Q P L F L K H
Cat Felis silvestris
Mouse Mus musculus Q3UHJ0 959 103328 P843 P P V A Q R L P S Q T E S V T
Rat Rattus norvegicus P0C1X8 962 103742 P846 P P V A Q R L P S H T E S V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_417663 953 102927 V839 A P L P Q C L V S Q T E S V A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_625109 598 65629 V581 V P T L P K P V N K T E S L S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40494 810 91014 T789 I S S E A T E T I V D V N V D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 N.A. 53.7 N.A. 80.7 79.9 N.A. N.A. 71.4 N.A. N.A. N.A. N.A. 36.7 N.A. N.A.
Protein Similarity: 100 99.6 N.A. 54.4 N.A. 83.1 82.7 N.A. N.A. 77.9 N.A. N.A. N.A. N.A. 50 N.A. N.A.
P-Site Identity: 100 100 N.A. 6.6 N.A. 6.6 6.6 N.A. N.A. 13.3 N.A. N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 100 100 N.A. 6.6 N.A. 20 20 N.A. N.A. 26.6 N.A. N.A. N.A. N.A. 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 38.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 50 0 13 25 13 0 0 0 0 0 0 0 0 0 13 % A
% Cys: 0 25 0 0 0 13 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 25 0 0 0 0 13 0 0 0 13 % D
% Glu: 0 0 0 13 0 0 13 0 0 0 0 50 0 0 0 % E
% Phe: 0 0 25 0 0 0 0 0 0 0 0 13 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 % G
% His: 0 0 0 0 0 0 13 0 0 13 0 0 0 0 13 % H
% Ile: 13 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % I
% Lys: 0 0 0 25 0 13 25 0 0 13 0 0 0 13 0 % K
% Leu: 0 0 13 13 0 0 38 0 25 0 13 0 13 38 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 25 0 0 0 13 0 25 0 13 0 0 % N
% Pro: 25 50 0 13 25 0 13 25 0 13 0 0 0 0 0 % P
% Gln: 0 13 0 0 38 13 0 13 13 25 0 25 0 0 0 % Q
% Arg: 0 0 0 0 0 25 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 13 13 0 0 0 0 0 38 0 0 0 75 0 13 % S
% Thr: 0 0 13 13 0 13 0 13 0 0 50 0 0 0 25 % T
% Val: 13 0 25 0 0 0 0 25 0 38 0 13 0 50 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _